tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1... - Names and Identifiers
tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1... - Physico-chemical Properties
tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1... - Introduction
tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate is an organic compound with the chemical formula C21H27FN4O3.
Nature:
-Appearance: White solid
-Melting point: about 110-115 degrees Celsius
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane, insoluble in water
-Molecular weight: about 406.46g/mol
Use:
- tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate can be used as a pharmaceutical intermediate, often in the pharmaceutical field for the synthesis of formulations and new drug development.
Preparation Method:
tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate can be synthesized by the following steps:
1. First, 4-fluorobenzoyl chloride and piperazine are reacted to form 4-fluorobenzoyl piperazine;
2. Then, 4-fluorobenzoyl piperazine is reacted with 2-cyanopyrimidine to form 4-(5-(4-fluorobenzoyl) pyrimidin-2-yl) piperazine;
3. Finally, 4-(5-(4-fluorobenzoyl) pyrimidin-2-yl) piperazine is reacted with tert-butanol acid to generate the target product.
Safety Information:
Since tert-Butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate is an organic compound, the following safety precautions should be paid attention to during operation and storage:
-Avoid contact with skin, eyes and respiratory tract. Appropriate protective equipment such as lab gloves, safety glasses and protective masks should be worn during operation.
-Avoid inhaling aerosols or dust, and ensure that the operation is carried out in a well-ventilated place. Use ventilation or personal respiratory protective equipment if necessary.
-Be careful when cleaning and handling to avoid dust. Use appropriate safe operating procedures for disposal or recycling.
-When storing, it should be stored in a sealed container, away from heat sources and flames.
Last Update:2024-04-09 21:01:54